Salinomycin, traditionally used as an anti-coccidial drug, has recently been shown to possess anti-cancer and anti-cancer stem cell (CSC) effects, as well as activities to overcome multi-drug resistance based on studies using human cancer cell lines, xenograft mice, and in case reports involving cancer patients in pilot clinical trials.

Salinomycin Na (55721-31-8) is a polyether ionophore with antibiotic and anti-cancer properties. It induces cell death in some types of cancer cell $ 30.00 – $ 80.00 Select options

Salinomycin Accession Number DB11544 Description Not Available Type Small Molecule Groups Vet approved Structure. Download . MOL SDF PDB SMILES InChI. Similar Structures. Structure for Salinomycin (DB11544) Salinomycin(Procoxacin) is an antibacterial and coccidiostat ionophore therapeutic drug.; IC50 Value:; Target: Antibacterial; Anticancer; Salinomycin, a polyether ionophore antibiotic isolated from Streptomyces albus, has been shown to kill CSCs in different types of human cancers, The salinomycin come in different sizes, packaging styles, and designs to address the various concerns of individuals and groups. If you are a farmer with many animals, you will find salinomycin in large packages to provide you with optimal transportation convenience.

Salinomycin

Methods Primary tumor-initiating Salinomycin is an antibiotic isolated from Streptomyces albus that selectively kills cancer stem cells (CSCs). However, the antitumor mechanism of salinomycin is unclear. This study investigated the chemotherapeutic efficacy of salinomycin in human prostate cancer PC-3 cells. We found that cytotoxicity of salinomycin to PC-3 cells was stronger than to nonmalignant prostate cell RWPE-1 Salinomycin, a commercially significant coccidiostat isolated from , has been synthesised from three principal fragments.

Salinomycin sodium | C42H69NaO11 | CID 23703990 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological 2017-03-28 · Salinomycin is a potent inhibitor of P-gp, which makes cells sensitive to chemotherapeutic drugs. 10 Salinomycin exhibits antibacterial activity, especially against Gram-positive bacteria, including various antibiotic-resistant species of Streptomyces. 2019-05-27 · Salinomycin is a powerful cancer treatment.

Salinomycin (71; R = H), obtained by culturing a strain of Streptomyces albus 〈72JAP(K)7225392〉, and narasin (71; R = Me), 4-(S)-methylsalinomycin, the main component of a polyether complex produced by Streptomyces aurofaciens 〈78JAN1〉 are now used to prevent coccidiosis, particularly in broiler chickens.

*Please select more than one item to compare. 1 match found for Salinomycin S4526-5MG.

Detailed Study on the Global Salinomycin Premix Market. A recent market study throws light on some of the leading factors that are likely to influence the growth of the Salinomycin Premix market in the upcoming decade.

Salinomycin sodium salt (Salinomycin sodium) shows selective activity against human cancer stem … Salinomycin (Sal), which is a polyether ionophore antibiotic from Streptomyces albus, has been proven to be able to kill different types of human cancer cells, most likely via interfering with ABC drug transporters, the Wnt/β-catenin signaling pathway, or other pathways. Salinomycin Accession Number DB11544 Description Not Available Type Small Molecule Groups Vet approved Structure. Download . MOL SDF PDB SMILES InChI.

1 Antibacterial activity; 2 Cancer research. 2.1 Pre-clinical. 3 Use in 4 Feb 2020 3.1 Salinomycin but not cisplatin attenuate cancer stem cell properties and promote apoptosis in colon CSCs. Several recent reports suggested Salinomycin sodium salt. Catalog # 3637.
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In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of Översättnings-API; Om MyMemory; Logga in Salinomycin analogs: Mechanistic probes and structure–activity relationships against cancer stem cells. Forskningsoutput: Avhandling › Doktorsavhandling (sammanläggning) 2019-11-25 · Salinomycin is administered to cancer patients via intravenous injection. Salinomycin treatment can be administered on its own, but it also has the potential to make cancer cells sensitive to other forms of treatment, allowing for a better response when used in conjunction with other therapies.

Salinomycin is a polyether ionophore with broad spectrum Gram positive and anti-coccidial activity. Salinomycin has a high affinity for monovalent cations, particularly potassium. Salinomycin is used to control coccidia in animals and for growth promotion in ruminants.
Is 1986

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Visit ChemicalBook To find more Salinomycin(53003-10-4) information like chemical properties,Structure,melting point,boiling point,density,molecular formula

A strategy with degenerate primers based on the polyether-specific epoxidase sequences was successfully developed to clone the salinomycin gene cluster. Using this Salinomycin is able to effectively eliminate CSCs and to induce partial clinical regression of heavily pretreated and therapy-resistant cancers.

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Salinomycin is as an antimicrobial and anticoccidial antibiotic. In 2009, a groundbreaking result was published in the scientific journal Cell (Ref), showing that Salinomycin can be effective in killing the cancer stem cells (CSC), the cancer cell population that is …

2019-05-27 · Salinomycin is a powerful cancer treatment. It is an antibiotic that’s been used to treat infections in poultry, but despite its demonstrated ability to cure human diseases like cancer and malaria, it is rarely used in humans because it would negate the need for conventional treatments like chemotherapy, radiation, and surgery. Salinomycin är ett antibiotikum som vanligtvis används för att förhindra infektioner inom fågelindustrin. Genom att använda salinomycin mot cancerceller som odlas i hypoxi hoppas jag se en större effekt på cancerstamceller eftersom hypoxi leder till fler stamcellsliknande egenskaper. Salinomycin och hypoxi Salinomycin induces apoptosis of human colorectal cancer cells, accompanied by accumulation of dysfunctional mitochondria and reactive oxygen species. These effects are associated with expressional down-regulation of superoxide dismutase-1 (SOD1) in response to salinomycin treatment.

2019-05-27

Poult Sci. 1986 Oct;65(10):1955-9.PubMed:3797377 Salinomycin is widely used in animal husbandry as a food additive due to its antibacterial and anticoccidial activities. However, its biosynthesis had only been studied by feeding experiments with isotope-labeled precursors. A strategy with degenerate primers based on the polyether-specific epoxidase sequences was successfully developed to clone the salinomycin gene cluster. Using this Salinomycin is able to effectively eliminate CSCs and to induce partial clinical regression of heavily pretreated and therapy-resistant cancers. It has also been demonstrated as a positive ionotropic and chronotropic agent that increased cardiac output, left ventricular systolic pressure, heart rate, mean arterial pressure, coronary artery vasodilatation and blood flow, and plasma 2019-02-14 · Objectives Salinomycin is a polyether antibiotic with selective activity against human cancer stem cells. The impact of salinomycin on patient-derived primary human colorectal cancer cells has not been investigated so far.

2 hours ago salinomycin/kg salinomycin sodium. — ≤ 10 g 20- desoxysalinomycin/kg salinomycin sodium. — ≤ 10 g 18,19- dihydrosalinomycin/kg salinomycin sodium.